Cystic fibrosis and HLA.

In 94 children suffering from cystic fibrosis, no abnormal frequencies of HLA 
markers of the A and B locus were observed in comparison 
with the distribution of these antigens in control series. Furthermore, the 
HLA genotypes of seven pairs of diseased sibs are incompatible with 
the hypothesis of a closed linkage between CF--an autosomal recessive transmitted 
disease--and HLA. 