Abnormal levels of prostaglandins and fatty acids in blood of children with cystic fibrosis.

12 children with cystic fibrosis (C.F.) had lower levels of the essential 
fatty acid, linoleic acid, in plasma and in red blood cells, 
than did control children, and production of prostaglandin F2alpha (P.G.F2alpha) was 
higher than in controls. After 10 months of oral linoleic-acid supplementation 
in 6 of the children with C.F., the linoleic-acid levels in 
plasma, red cells, and platelets were higher and P.G.F2alpha production was 
lower than in the 6 children with C.F. who received a 
placebo lipid. Prostaglandin F2alpha is associated with bronchoconstriction and its increased 
production in children with C.F. might be causally related to their 
chronic pulmonary disease. 