Mucoid Pseudomonas aeruginosa and cystic fibrosis: resistance of the mucoid from to carbenicillin, flucloxacillin and tobramycin and the isolation of mucoid variants in vitro.

Mucoid strains of Pseudomonas aeruginosa isolated from the sputa of patients with 
cystic fibrosis or in vitro through selection with phage were more 
resistant to carbenicillin, flucloxacillin and tobramycin and more sensitive to tetracycline 
than related non-mucoid strains. The observations led to the development of 
a technique for the isolation of mucoid variants in vitro based 
on enhanced resistance to carbenicillin. Mucoid variants were isolated from various 
strains of Ps. aeruginosa and the exopolysaccharide found to be similar 
to that obtained from mucoid Ps. aeruginosa isolated from patients with 
cystic fibrosis. 