C3 polymorphism in a Danish cystic fibrosis population and its possible association with antibody response.

The C3 types of human serum are reported for a material of 
113 Danish cystic fibrosis patients, age 0-30 years. The frequency of 
the C3F gene was 0.2832 which was significantly higher (p less 
than 0.0005) than the frequency found in a control group of 
224 healthy babies (C3F = 0.1585). It also differed significantly (p 
less than 0.01) from the C3F gene frequency of 0.1780 found 
in 177 blood donors, age 20-24 years. A significant association between 
any of the C3 phenotypes and the most serious infection in 
cystic fibrosis, chronic mucoid P. aeruginosa infection, or the antibody response 
against these bacteria was not found. 