Urinary cyclic nucleotides in adult male cystic fibrosis patients.

Urinary adenosine 3':5' (cyclic) monophosphate and guanosine 3':5' (cyclic)-monophosphate excretion are significantly 
elevated in adult male cystic fibrosis patients compared to normal men 
when values are expressed in ways which consider the smaller size 
of the cystic fibrosis subjects of the same age. Cystic fibrosis 
patients excreted 3.22 +/- 1.16 nmol adenosine 3':5' (cyclic)monophosphate/g creatinine per 
24 h vs. 1.97 +/- 0.43 for normal men (p less 
than 0.02); and cystic fibrosis patients excreted 0.50 +/- 0.16 nmol 
guanosine 3':k' (cyclic)monophosphate/g creatinine per 24 h vs. 0.30 +/- 0.07 
for normal men (p less than 0.05). Subjects were all adults 
who had completed linear growth and sexual development, thus eliminating any 
possible effects of slower maturation of cystic fibrosis patients, and all 
subjects were male, thus avoiding the fluctuation of urinary cyclic nucleotides 
with the menstrual cycle, problems which had complicated interpretation of previous 
studies. 