The influence of cystic fibrosis serum and calcium on secretion in the rabbit tracheal mucociliary apparatus.

Cystic Fibrosis serum or its isolated component IgG fraction and calcium ionophore 
A23187 all produced a quantitatively greater increase of mucus glycoprotein secretion 
in the rabbit tracheal epithelium than did control serum or its 
isolated component IgG fraction. These values were determined by dry weight 
secretion per gram of tissue and on subsequent sialic acid content 
of secretions. This demonstrable increase in mucus production represents a measurable 
difference in the functioning of the cultured mucociliary apparatus due to 
the influence of cystic fibrosis serum. 