Cimetidine in cystic fibrosis [letter].

A pilot study has examined the effect of cimetidine on steatorrhea in 
children with pancreatic insufficiency due to CF who were receiving pancreatic 
supplements. Administration of cimetidine with pancreatic supplements reduced the faecal fat 
excretion in 4 out of 5 children, in 3 cases by 
more than 50%. In Case 4 steatorrhea increased on cimetidine but 
without any symptoms and we have no explanation for it. None 
of the children had any side effects from the drug. Further 
studies are needed to determine the indications of cimetidine in the 
dietary management of CF. 