Role of antibody in infections due to Pseudomonas aeruginosa.

Various techniques have been utilized for measurement of antibodies against Pseudomonas aeruginosa. 
In general, the results of such measurements tend to parallel each 
other, but the principal functional antibodies against Pseudomonas appear to be 
opsonins of the IgG and IgM immunoglobulin classes. These antibodies are 
potentiated by the complement system, activated either through the "classical" or 
"alternate" pathways. Susceptibility to fatal infection with Pseudomonas is associated with 
antibody deficiency, but this defect is usually correlated with other data 
regarding the state of the host, such as underlying disease, immunosuppressive 
therapy, and functional leukopenia. Additional information is needed on the relative 
protective role of IgG and IgM antibodies, the affinity of such 
antibodies for viable bacteria, and the role of antibodies against nonlipopolysaccharide 
antigens, such as protein components of the cell wall and Pseudomonas 
exotoxins. 