Prolonged obstructive jaundice and giant cell hepatitis in an infant with cystic fibrosis [letter].

Histologic evidence of liver involvement, consisting of focal biliary cirrhosis and/or intrahepatic 
mucus, is a frequent autopsy finding in infants with cystic fibrosis 
(CF). We wish to report an infant with CF in which 
liver biopsy showed features typical of neonatal giant cell hepatitis. In 
our patient, none of the pathologic features usually described in CF 
were present in either of the biopsies. Rather, the changes were 
those described in neonatal hepatitis and, to our knowledge, have not 
been reported in association with CF. It is likely that the 
giant cell hepatitis was a coincidental finding, unrelated to CF. It 
emphasizes, however, that one cannot assume a uniform etiology for all 
instances of obstructive jaundice seen in infants with CF. 