Therapeutic approach to pancreatic extract-induced hyperuricosuria in cystic fibrosis.

The relationship between the dosage of pancreatic extract and the excretion of 
uric acid was investigated in 29 patients with cystic fibrosis and 
exocrine pancreatic insufficiency. Urinary excretion of uric acid was normal in 
patients receiving small doses of pancreatic extracts and abnormally high in 
those receiving large amounts. In the latter group, normouricosuria was achieved 
by reducing the dose of pancreatic extract. Normal stool patterns and 
adequate weight gains were preserved by a diet modification that was 
well accepted by the patients. To eliminate the potential renal consequences 
of hyperuricosuria, it seems appropriate to control the need for increasing 
amounts of pancreatic enzymes by limiting the dietary intake of fat 
and maintaining a positive caloric and nitrogen balance with high intake 
of protein and carbohydrates and supplementation with medium-chain triglycerides. 