Normal plasma arginine esterase and the Hageman factor (factor XII) -prekallikrein-kininogen system in cystic fibrosis.

Previous investigators have suggested that the biological activity of plasma prekallikrein is 
defective in cystic fibrosis. In contrast, no such difference was demonstrable 
between normal and cystic fibrosis plasma. Esterolytic activity for the synthetic 
substrate p-toluene sulfonyl-arginine methyl ester (TAMe) evolved normally in cystic fibrosis 
plasma treated with chloroform and ellagic acid, a measure of generation 
of plasma kallikrein. Additionally, plasma prekallikrein (Fletcher factor) and high molecular 
weight kininogen (Fitzgerald factor), a substrate of plasma kallikrein, were normal. 
Thus, the concept that cystic fibrosis is associated with abnormalities in 
the plasma kallikrein-kinin system could not be supported. 