Utilization of electron microscopy in the prenatal diagnosis of genetic disease.

The use of electron microscopy as a further method of diagnosis of 
disease in cultured skin fibroblasts and cultured amniotic fluid fibroblasts is 
presented. It was demonstrated that Tay-Sachs disease, Fabry's disease, and metachromatic 
leukodystrophy had distinctive abnormalities in both cultured skin fibroblasts and cultured 
amniotic fluid fibroblasts. It was shown that control of culturing conditions 
made it possible to distinguish normal cell lines from certain cell 
lines carrying known genetic diseases. 