Minocycline in the antibiotic regimen of cystic fibrosis patients: weight gain and clinical improvement.

Minocycline hydrochloride was given to 100 patients with cystic fibrosis of the 
pancreas for periods of 3 months over a broad- spectrum antibiotic 
drug rotation which lasted 2 years. Increased weight gain and some 
clinical improvement was seen during treatment with minocycline. Those patients with 
severe disease gained more weight than those with mild or moderate 
disease, and males gained more than females. When minocycline hydrochloride was 
not the drug in use, patients lost weight and their health 
declined. 