Vitamin E.

In this review, we make a deliberate attempt to put all the 
information on vitamin E requirement, absorption, metabolism, and function in both 
animals and man in better perspective. The large clinical trials in 
which vitamin E was given at pharmacological levels for presumed medical 
indications, as well as trials of vitamin E for bona fide 
deficiency disease in man, will be extensively reviewed. Nutritional aspects discussed 
include dietary intake, biological activity, the evaluation of nutritional status, and 
the relationship to dietary polyunsaturated fatty acids. Metabolism concerns include absorption, 
transport and deposition, and cellular function. Clinical aspects include deficiency states, 
approaches to therapy, and possible pharmacological effects. 