Somatic cell genetic studies of cystic fibrosis.

The expression of the gene coding for the cystic fibrosis ciliary inhibitor 
has been examined in somatic cell hybrid clonal lines. Hybrids were 
produced by the fusion of cultured skin fibroblasts from cystic fibrosis 
patients with mouse RAG and LM (TK-) cell lines. The ciliary 
inhibitor was detected by the oyster ciliary assay in several primary 
hybrid clones but not detected in others, indicating the segregation of 
an associated nuclear gene. 