Expression of the cystic fibrosis genotype in cultured somatic cells.

Observations on the characteristics of the cell with the cystic fibrosis (CF) 
genotype in culture are reviewed. Although numerous and diverse abnormalities have 
been described, none were specific for the CF gene. The relevance 
of each of these abnormalities to the clinical syndrome known as 
CF is discussed, emphasizing that the value thus far of such 
cell culture research has been to learn how the CF gene 
influences cellular function. 