Treatment of pseudomonas infections in cystic fibrosis using tobramycin.

It was decided to treat all seventeen cystic fibrosis patients under our 
care who were known to have active infection with mucoid strains 
of Pseudomonas, using large intravenous doses of tobramycin. By the objective 
observations made, results were not so satisfactory. Changes in white blood 
cell count and erythrocyte sedimentation rate seemed often to conflict with 
clinical impression of improvement. However, there was closer agreement between subjective 
judgements, weight gain and respiratory function changes. Eradication of Pseudomonas from 
the sputum was achieved in four cases, although the duration of 
follow-up in one was very short. 