Pathophysiology of mucus secretion in cystic fibrosis.

Abnormality of mucus secretion, either biochemical or physical, has long been claimed 
to be the primary cause of pulmonary complications - obstruction and 
infection - in patients suffering from cystic fibrosis (CF). This review 
will draw in large measure on the experience of Prof. L. 
Reid and her research team who over the last 15 years 
have studied mucus-secreting structures and their secretions in the normal and 
diseased lung from various angles: development, structure and ultrastructure, histochemistry organ 
culture, biochemical analysis and rheological characterization. 