Studies on immunoglobulins in healthy children in various stages of development and in the chosen illnesses.

The studies were carried out with view to evaluate development of immunoglobulins 
biosynthesis in children from birth through first year of life and 
up to age of 15 years as well as to establish 
the normal values of each immunoglobulin class in healthy children of 
different age in our conditions of investigations and in our geografical, 
social and economical situation. There was also under consideration the evaluation 
of body reaction on antigenic stimulation and administration of gammaglobulin preparations. 
In order to determine more broadly the development of these humoral 
immunity parameters in children qualitative and quantitative investigations of immunoglobulins were 
undertaken also in same chosen illnesses where changes in biosynthesis and 
metabolism of immunoglobulins may be connected with pathogenesis of illness or 
with type of treatment (cystic fibrosis) (C.F.), Ataxia-Telangiectasia syndrome (A-T), pituitary 
dwarfism, fenyloketonuria (PKU). In some groups of children investigations were systematically 
repeated to evaluate the dynamism of changes. 