Studies in meconium: disaccharidase activities in meconium from cystic fibrosis patients and controls.

Meconium ileus represents the earliest clinical manifestation of cystic fibrosis. The differences 
found in the composition and amount of protein, mucoprotein, mucopolysaccharides, and 
reducing sugars in meconium from newborns with cystic fibrosis might be 
of significance relative to the pathogenesis and early diagnosis of this 
disease. We studied the enzymatic activity of disaccharidases (lactase, sucrase, maltase, 
and palatinase) in meconium of infants with cystic fibrosis and controls. 
We found an increase in the specific activity of these enzymes 
in the meconium from infants with cystic fibrosis as compared to 
the specific activity in meconium from normal infants. The increase in 
the activities, expressed as micromols per gram of protein per minute 
was: lactase, 100 times higher; sucrase, 18 times; maltase, 4.8 times, 
and palatinase, 8.9 times. 