Immediate hypersensitivity in patients with cystic fibrosis.

Twenty-three out of thirty patients with cystic fibrosis gave strong immediate skin 
hypersensitivity reaction to a wide variety of allergens. Seventy-five per cent 
of these had a markedly elevated serum IgE concentration whereas those 
patients who had negative Type 1 immediate skin reactions also had 
normal levels of serum IgE. The sputum of those patients with 
immediate skin reactivity also had positive precipitins to a variety of 
antigens. 