Additional data on hepatic function tests in cystic fibrosis.

Fifty cystic fibrosis (CF) patients, of whom 9 had multilobular cirrhosis, were 
observed regularly for a period of 3 years and various liver 
function tests, indicating cytolysis, cholestasis and cellular insufficiency were performed. Immunoglobulin 
and prothrombin were assayed. In 9 patients with cirrhosis, the tests 
were generally abnormal. Two distinct biochemical patterns of cirrhosis were distinguished, 
one clearly cholestatic and the other of a more cellular type. 
The distinction was made on the basis of the IgA : 
Transferrin ratio and of gamma-glutamyl-transpeptidase levels. In the non-cirrhotic patients, a 
temporary increase of cytolysis and cholestasis was observed in 50% of 
the cases. 