Defects in the cell cycle of fibroblasts obtained from patients with cystic fibrosis.

This paper analyzes the cell cycle of cystic fibrosis-derived fibroblasts and statistically 
demonstrates their failure to support a normal population doubling time in 
vitro and indicates that this is due largely to a failure 
of the cystic fibrosis-derived cells to enter the cell cycle in 
normal numbers. We have no explanation for the significant difference in 
the behavior of these cells from patients with cystic fibrosis vis-a-vis 
either normal or disease control fibroblasts, save to conclude that it 
proceeds from an intrinsic property of the cells themselves. 