Chemical comparison of normal and cystic fibrosis meconium: a quantitative and qualitative analysis of carbohydrate splitting enzymes.

Meconium specimens from more than 200 normal and premature and from 5 
cystic fibrosis newborns were analyzed for their level of several glycosidases. 
Considerable scatter of activities were found in all three groups studied 
and no evidence for any relation of such scatter with the 
blood group-specific A, B, AB, H substances was found. Alpha-glucosidase, an 
acid glycosidase found elevated in CF serum and fibroblasts, was elevated 
in all CF meconium extracts including that which had a very 
low albumin content. 