Bronchial provocation tests in cystic fibrosis.

Patients with cystic fibrosis have a higher incidence of positive skin prick 
tests than normal; this may be the result of defective antigen 
handling at mucosal surfaces. Our aim was to investigate bronchial allergy 
in a group of children with CF and positive skin tests. 
We studied 15 children aged 7 to 16 years with mild 
to moderate respiratory disease. Only 1 child gave a history of 
wheezing not associated with chest infections and this study supports the 
hypothesis that clinical asthma is a product of bronchial allergy and 
broncholability. The responses to bronchial provocation with Aspergillus suggest that allergy 
to this antigen may play a part in the pathogenesis of 
lung disease in some patients with CF. 