Prostaglandins and cystic fibrosis.

We have investigated two aspects of prostaglandin function in cystic fibrosis: the 
response of platelets to PGE1, and the concentrations of PGE2 and 
PGE-alpha in the sweat. Low concentrations of PGE1 have less effect 
on platelet agglutination in CF patients and heterozygotes than in normals, 
but no difference is observed when high PG concentrations are used. 
Sweat PGE2 and PGE-alpha concentrations are similar in normals, CF patients 
and heterozygotes, but sweat PGE2 concentrations are proportional to Na/Cl levels 
in CF, but not in control children or heterozygotes. 