Serum-angiotensin-converting-enzyme in chronic granulomatous disease [letter].

We have studied serum-angiotensin-converting-enzyme (SACE) in sarcoidosis and other granulomatous disorders. We 
have measured SACE in 10 randomly chosen, consecutive patients with chronic 
granulomatous disease (CGD) and in some of their family members and 
in 5 children with cystic fibrosis and severe chronic pulmonary involvement. 
SACE levels in the patient with CGD differed significantly from those 
of normal controls and those of family members and patients with 
cystic fibrosis. Our preliminary studies show that CGD is associated with 
increased levels of SACE. 