Normal neutrophil and monocyte chemotaxis in patients with cystic fibrosis.

The prominent role of infection in the clinical course of cystic fibrosis 
has led to considerable investigation of possible immune deficiency in these 
patients. Leukotaxis of circulating phagocytic cells and the ability to generate 
chemotactic factors are important in host defenses against bacterial invasion. These 
properties were investigated in patients with clinically stable cystic fibrosis to 
determine if they possess dysfunctional inflammatory responses which would predispose them 
to severe infection. 