HLA determinants in families with more than one member with cystic fibrosis [letter].

Attempts to identify the carrier state for cystic fibrosis (CF) or to 
make a prenatal diagnosis of CF have been unsuccessful. One approach 
to this problem is to look for associations between known genetic 
markers and the locus for CF. In general these studies have 
looked at the frequency of HLA types in patients with CF 
and have failed to demonstrate a strong association. We attempted to 
look for linkage between HLA haplotypes and CF in families with 
more than one affected member. The segregation of HLA in these 
affected sibpairs vary little from the expected. Although the sample size 
is small, it is unlikely that a close linkage exists between 
the HLA loci and the CF locus. 