Cystic fibrosis: decreased thermostability of alpha-mannosidase in crude extracellular fluids of patients and carriers.

We wish to demonstrate that an abnormal thermostability has been found in 
crude extracellular fluids for alpha-mannosidase. More extensive studies involving several of 
the 'leaky' hydrolases are under way and they indicate that the 
observed thermolabilities can be exploited to develop the urgently needed simple 
diagnostic tools for cystic fibrosis. 