Study of the oligosaccharide units from mucus glycoproteins of meconium from normal infants and from cases of cystic fibrosis with meconium ileus.

1. The mucus glycoproteins in meconium from normal infants and from infants 
having cystic fibrosis with meconium ileus have been studied. 2. Whereas 
normal meconium contained about 50% protein-bound carbohydrate, the meconium from cystic 
fibrosis contained only about 10%. 3. Glycopolypeptides were prepared from the 
mucus of glycoproteins. The oligosaccharide units from this material were released 
and fractionated. The fractions ranged widely in size and composition. 4. 
The fractions from cystic fibrosis specimens had a significantly higher content 
of fucose than those from normal specimens. 