Allergy in cystic fibrosis.

Forty-four patients with cystic fibrosis, sixty-seven parents, and thirty-nine controls were compared 
with regard to their immediate cutaneous hypersensitivity, total and specific serum 
IgE and serum IgG4 concentrations. The patients had increased prick test 
reactions and specific IgE to Aspergillus fumigatus. The development of reactions 
to A. fumigatus correlated with the severity of the disease. There 
were no other significant differences when serum total IgE, specific IgE 
and IgG4 concentrations or skin test reactivity were compared in the 
patients, parents and controls. 