Evaluation of the single-breath diffusing capacity in asthma and cystic fibrosis.

To explain why the single-breath carbon monoxide diffusing capacity (Dsb) was, on 
the average, elevated in 163 asthmatic subjects and 175 patients with 
cystic fibrosis, we simulated this elevation in ten normal subjects by 
having them perform the test for Dsb through an inspiratory obstruction. 
This resulted in an 18 percent increase in Dsb corrected for 
pulmonary volume. Inhalation of a bronchodilator drug was associated with relief 
of obstruction and a fall in the corrected Dsb in 31 
asthmatic subjects but did not change either the obstruction or the 
corrected Dsb in 17 patients with cystic fibrosis. We suggest that 
elevated Dsb in asthma and cystic fibrosis is partly due to 
maximal inspiration against obstructed airways. This requires abnormally negative intrathoracic pressures, 
increasing the pulmonary capillary blood volume, and, thereby, increasing the Dsb. 
