Biological activities of cystic fibrosis serum. III. CF serum induced uptake of 45Ca++ by rabbit tracheal explants.

Cystic Fibrosis (CF) serum and its isolated component IgG fraction produce an 
increased uptake of 45Ca++ in rabbit tracheal explants when compared to 
control serum and its isolated IgG fraction. Heterozygote serum also produced 
an increased uptake of 45Ca++ but not to the same extent 
as CF serum. The calcium channel blocker D600 inhibited the CF 
serum induced uptake of 45Ca++ indicating that CF serum may be 
acting on the plasma membrane to produce changes in calcium permeability 
in rabbit tracheal explants. 