The pulmonary circulation: remodeling in growth and disease. The 1978 J. Burns Amberson lecture.

This account draws on studies of young and mature lung, on normal 
and morbid anatomic features, on normal adaptations as in growth, and 
remodeling by disease. Qualitative analysis of the vascular bed, development of 
the pulmonary circulation, right ventricular hypertrophy or cor pulmonale, remodeling in 
disease, and experimental studies are discussed. Pulmonary hypertension offers us a 
complex pattern of structural and functional interaction; we are just beginning 
to realize how complex it is. Information on normal structure, its 
modification and remodeling by growth and disease, and appropriate techniques are 
available that will enable us to formulate our questions with due 
regard for anatomic precision and functional implication. And so research will 
lead to understanding and, it can be expected, to control of 
the undesirable aspects of pulmonary hypertension. 